"Armenicum" Clinical Center was established in 1999, on the base of Infectious Clinical Hospital N1, the aim of which was the treatment of patients with infectious diseases, including HIV infection, as well as carrying out investigations and clinical studies of the drug "Armenicum"
Clinical Center is equipped with up-to-date facilities; a group of infectious disease doctors was formed. At present, the clinical center of more than 10-years history, meet the required standards of the contemporary medicine.
There are box department, departments of infectious diseases, intensive care unit, resuscitation unit, clinical-diagnostic laboratory, equipped with modern facilities, a surgical department intended for the patients with various infections is planned to be established.
HIV-infected patients, requiring qualified diagnostics and treatment of opportunistic diseases, such as: pneumocystic pneumonia, various mycoses (cryptococcosis, coccidioidomycosis, histoplasmosis, systemic candidiasis, etc.), atypical mycobacteriosis, cerebral toxoplasmosis, viral infections (CMV, herpetic infections, etc.), as well as associated viral hepatitis, undergo a medical examination at the Clinical Center.
Drug “Armenicum” use for treatment of HIV-infected patients with opportunistic infections viral, bacterial, protozoal, fungal aetiology. The treatment course consists of 4 cycles with 3- week interval. Each treatment cycle includes 3 infusions administered every other day, i.e. 12 infusions per treatment course. In the intervals between the treatment cycles, patients do not require in-patient treatment.
According to the data of the clinical studies, drug therapy with Armenicum is well-tolerated, side effects (fever, chills, headache, weakness, etc.) are transient and do not require discontinuation of treatment or special treatment. Hematological and biochemical parameters of blood analysis of the patients with HIV infection in the dynamics of treatment with the drug "Armenicum" is the indicative of the drug safety, absence of side-effects on the functional activity of hemopoietic organ and circulating cell components, on blood rheological properties and functioning of most important organs and systems. The drug also improves the metabolism in the liver.
The clinical studies have shown that the drug "Armenicum" action is manifested by an increase of CD4 + T-lymphocytes count in peripheral blood; decrease of HIV viral load and by significant improvement of HIV-infected patients' quality of life, affecting the adherence to the treatment.
No sharp, significant and stable suppression of HIV replication, usually occurring at classical antiretroviral drugs administration, is determined in the dynamics of changes in viral load of HIV-infected patients received treatment with drug "Armenicum". The drug "Armenicum" by its character of action on VL is similar to the drugs affecting HIV replication via other mechanisms, i.e. suppressing the fusion and entry of HIV into target cells and/or modulation of nonspecific and adaptive anti-HIV immune response. Data on the significant improvement of the clinical course of HIV infection and patients' quality of life, as well as data indicating that the drug effect on HIV replication exceptionally depends on the dynamics of cells population and redistribution and death of HIV- infected CD4 + T- cells in the body are the evidence of the above mentioned.
Armenicum possesses systemic immunomodulatory property, resulting in improvement of cell-mediated immunity parameters of HIV-infected patients (reliable increase of CD4 + T-lymphocytes' count in peripheral blood), cytokines production (tumor necrosis factor-alpha, soluble interleukin-2 receptor) and other humoral factors (beta-2 microglobulin); drug contributes to the normalization of the humoral immune response in HIV-infected patients, displayed by reduction of serum immunoglobulin G and A content.
According to the dynamics of the clinical symptoms a positive effect of the drug "Armenicum" on the course of some associated/opportunistic diseases was determined. Among them mainly were dermatosis, such as seborrheic dermatitis, ostio-folliculitis, oral candidiasis, recurrent furunculosis, foot mycosis, pointed candyloma, recurrent herpetic infection: labial and genital herpes. Iodine-containing high polymer Armenicum does not damage the thyroid profile of HIV-infected patients and is safe for thyroid gland functioning.
The clinical trials of the drug are being continued in the clinical center with the aim of revealing the spectrum of "Armenicum" drug effect on the treatment of various diseases. Encouraging and positive data on previously carried out pilot studies gave us a basis for conducting clinical trials in patients with hepatitis C, systemic lupus, burns and various dermal lesions in order to reveal the essential scientific conclusions for further use of the drug "Armenicum" for the treatment of the above-mentioned diseases.
Patients with various infectious diseases, such as acute viral hepatitis, respiratory and intestinal infections, brucellosis, etc. are examined and receive hospital treatment in the frame of government order (public financing). Apart from the diseases included in the list of government order, patients with liver diseases, such as chronic and toxic hepatitis, hepatocirrhosis, steato-hepatosis, as well as patients with certain systemic diseases, accompanied by immune system disorders also receive a hospital treatment in the clinical center.
Since 2006 a new period has started in the history of the clinical center "Armenicum": the center has begun to function as an infectious clinic, as far as all the appropriate conditions required were available, in particular the presence of the Department of Infectious diseases of Yerevan State Medical University, named after M.Heraci on the hospital basis as well as the qualified medical staff availability.
In addition to medical and scientific activities an educational activity is also being performed at the Clinical Center "Armenicum". Here is the Department of Infectious Diseases YSMU, named after M. Heraci. Future physicians have the opportunity to become familiar with the newest and modern leading methods of diagnostic applied in medicine, practice the acquired knowledge and participate in scientific progressions achieved in the clinical center.